Peyronie's Disease
Peyronie’s disease at a glance
Peyronie’s disease is a condition where scar tissue forms inside the penis that can cause bending or narrowing of the penis during an erection.
Peyronie’s disease can cause pain and erectile dysfunction, which can result in the man avoiding sexual situations and can cause significant emotional stress.
In mild cases, the symptoms of Peyronie’s disease sometimes dissipate on their own, but severe cases may require treatment.
What is Peyronie’s disease?
Peyronie’s (pay-roe-NEEZ) disease is a condition that causes the penis to curve when erect because of scar tissue that forms inside the penis. This scar tissue is also called plaque. The plaque can form in any part of the penis.
Peyronie’s disease can cause pain and significant bending of the penis. Although it is normal for some men’s penises to bend slightly during erection, Peyronie’s disease often causes a more significant bend. It also causes significant mental and emotional stress for men who suffer from the condition.
Peyronie’s disease can cause complications including:
  • Erectile dysfunction (problems with maintaining or achieving an erection)
  • Inability to have sexual intercourse
  • Anxiety or stress regarding the appearance of the penis or sexual ability
  • Stresses on the man’s relationship with his sexual partner
  • Difficulty fathering a child, because intercourse is difficult or impossible.
Up to 10 percent of men experience this condition. The exact prevalence is unknown, however, because men do not always report it. Peyronie’s disease is most common in middle-aged men, although older and younger men also can experience it. In some cases, it can cause serious problems if it is not corrected.
Unique offer only for AMS patients
Special prices. Individual approach. Urgent treatment plan.
Causes of Peyronie’s disease
Doctors do not know the exact cause of Peyronie’s disease, although it is possible that several factors could be involved.

Most often, doctors believe Peyronie’s disease occurs after an injury to the penis. This injury often occurs during vigorous sexual activity. Most patients, however, don’t remember any specific injury.

Some men notice a gradual onset of Peyronie’s disease. In these cases, the condition may not be related to any particular injury. Researchers theorize that there might be some inherited tendency toward Peyronie’s disease, or that it might be connected to certain health conditions.
Another possible cause of Peyronie’s disease is that with age, the tissues in the penis can be injured more easily and don’t heal as well, causing scar tissue to build up.

It is also possible that smoking and having some types of surgery for prostate cancer or benign prostatic hyperplasia (BPH) could carry a higher risk of Peyronie’s disease. Some medications list Peyronie’s disease as a possible side effect, but researchers haven’t linked the condition definitively to any medications.
Symptoms of Peyronie’s disease
During a normal erection, cavities or sponge-like spaces in the penis fill with blood. These areas normally stretch to allow the penis to become erect. With Peyronie’s disease, the scar tissue in these areas does not stretch. As a result, the penis must bend to accommodate the non-stretching tissue. This bending can be significant and quite painful.
Peyronie’s disease signs and symptoms might appear suddenly or develop gradually. The most common indicators include:

A bent or curved penis. Peyronie’s disease causes the penis to curve either upward, to one side or downward when erect. Sometimes a tight band of scar tissue forms around part of the penis.
Scar tissue. This forms under the skin of the penis and can feel like lumps or hard bands.
Erectile dysfunction.
Penis becomes shorter.
This can be present when the penis is flaccid or when it is erect.
Dupuytren’s contracture. This condition is the development of fibrosis in the palm of the hand. About 30 percent of men who have Peyronie’s disease also have Dupuytren’s contracture or other fibrosis in other areas of the body.
Over time after Peyronie’s disease is detected, the associated penis curvature might gradually worsen. At some point, however, it stabilizes for most men.
Diagnosis of Peyronie’s disease
Most men with Peyronie’s disease find that the pain they experience during erections gets better in one or two years. Still, the scar tissue and the curvature usually remain.

For 10 percent of men with Peyronie’s disease, the symptoms go away without treatment. But for most men, symptoms stay the same or get worse. Treatment is usually necessary if the curvature is so severe that it makes sexual intercourse impossible.
Before deciding on a course of treatment, physicians may do the following examinations:

Physical exam. The doctor will feel the penis to check for scar tissue and identify its location. The doctor also might take measurements as a baseline to tell later if the disease has shortened the penis. To evaluate the condition of the penis when it is erect, physicians may request that the patient bring photos taken at home of the erect penis.
If the physician needs more information about the extent and effects of scar tissue, he or she might order imaging tests, such as ultrasound, to study the erect penis and evaluate scar tissue, blood flow and other visual information. In some cases, a medication is injected into the penis to make an erection prior to the ultrasound.
If the condition has come on suddenly, or if the doctor can’t verify Peyronie’s disease through a physical exam, he or she might perform a biopsy. This procedure takes a sample of tissue for laboratory examination. The purpose is to rule out other conditions that could be causing the symptoms.
Unique offer only for AMS patients
Special prices. Individual approach. Urgent treatment plan.
A man suffering from Peyronie's disease will first notice a suspicious nodule on the penis (fibrous scar) and a curvature of the penis to one side during erection. In addition, pain, the initial phase of erectile dysfunction, shortening or narrowing of the penis may occur.
Non-surgical treatment is effective if the man presents himself within the first month after the onset of symptoms
Low intensity shock waves (LSWT) are used to reduce pain.
Injections of serum enriched with activated platelets and hyaluronic acid (PRP+HA), traction (Andropenis) and vacuum devices (VEP) are used to stop scar formation.
To correct the curvature, surgical intervention is performed
Surgical treatment of Peyronie's disease
​The surgical method is based on the geometric principles of achieving the largest possible size and diameter of the penis up to the maximum stretch limit of nerves, blood vessels and urethra.
Removal of nodules from the penis
Correcting the curve
Restoring the lost length and width of the penis
Installation of a penile implant

​Peyronie's disease surgery is not performed in the active phase of the disease.

The duration of the operation is about 3 hours.
Hospital stay is 1 to 2 days.
Postoperative outpatient follow-up is performed every other day.
Return to work is after 7 days.

After 6 weeks you can continue physical activities (training, gym, but not swimming pool, and not sauna). The beginning of sexual relations is allowed 5 weeks after the operation. Six weeks after Peyronie's surgery, there are no signs of surgery. The recovery process is further simplified by the use of resorbable sutures during surgical intervention. Threads placed externally on the skin disappear in two weeks, and internal threads dissolve naturally no later than two months after surgery.

​Patients receive aesthetically natural, fully functional, permanent results from surgical treatment of Peyronie's disease

​The innovative surgical technique, developed by Dr. Nikola Stanojević in cooperation with a team of international experts, involves the least possible trauma to the noble tissue of the penis during the surgical intervention itself. Complete reconstruction of the shape and size of the penis with the installation of a penile prosthesis is performed through a small incision towards the scrotum. With this approach, a completely natural appearance is obtained after surgery, and no one can recognize that the man has ever had surgery.